Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.13091/687
Title: Antibacterial Activity of Linezolid against Gram-Negative Bacteria: Utilization of epsilon-Poly-l-Lysine Capped Silica Xerogel as an Activating Carrier
Authors: Kaya Güzel, Gülcihan
Medaglia, Serena
Candela-Noguera, Vicente
Tormo-Mas, Maria Angeles
Marcos, Maria Dolores
Aznar, Elena
Martinez-Manez, Ramon
Keywords: Antibacterial Activity
Linezolid
Mesoporous Material
Silica Xerogel
Surface Modification
Drug-Delivery
Aerogel
Nanoparticles
Spectrum
Vancomycin
Nanofibers
Solvents
Overcome
Option
Issue Date: 2020
Publisher: MDPI
Abstract: In recent times, many approaches have been developed against drug resistant Gram-negative bacteria. However, low-cost high effective materials which could broaden the spectrum of antibiotics are still needed. In this study, enhancement of linezolid spectrum, normally active against Gram-positive bacteria, was aimed for Gram-negative bacteria growth inhibition. For this purpose, a silica xerogel prepared from a low-cost precursor is used as a drug carrier owing to the advantages of its mesoporous structure, suitable pore and particle size and ultralow density. The silica xerogel is loaded with linezolid and capped with epsilon-poly-l-lysine. The developed nano-formulation shows a marked antibacterial activity against to Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. In comparison to free linezolid and epsilon-poly-l-lysine, the material demonstrates a synergistic effect on killing for the three tested bacteria. The results show that silica xerogels can be used as a potential drug carrier and activity enhancer. This strategy could provide the improvement of antibacterial activity spectrum of antibacterial agents like linezolid and could represent a powerful alternative to overcome antibiotic resistance in a near future.
URI: https://doi.org/10.3390/pharmaceutics12111126
https://hdl.handle.net/20.500.13091/687
ISSN: 1999-4923
Appears in Collections:Mühendislik ve Doğa Bilimleri Fakültesi Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collections
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collections
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collections

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