Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.13091/687
Title: Antibacterial Activity of Linezolid against Gram-Negative Bacteria: Utilization of epsilon-Poly-l-Lysine Capped Silica Xerogel as an Activating Carrier
Authors: Kaya Güzel, Gülcihan
Medaglia, Serena
Candela-Noguera, Vicente
Tormo-Mas, Maria Angeles
Marcos, Maria Dolores
Aznar, Elena
Martinez-Manez, Ramon
Keywords: Antibacterial Activity
Linezolid
Mesoporous Material
Silica Xerogel
Surface Modification
Drug-Delivery
Aerogel
Nanoparticles
Spectrum
Vancomycin
Nanofibers
Solvents
Overcome
Option
Publisher: MDPI
Abstract: In recent times, many approaches have been developed against drug resistant Gram-negative bacteria. However, low-cost high effective materials which could broaden the spectrum of antibiotics are still needed. In this study, enhancement of linezolid spectrum, normally active against Gram-positive bacteria, was aimed for Gram-negative bacteria growth inhibition. For this purpose, a silica xerogel prepared from a low-cost precursor is used as a drug carrier owing to the advantages of its mesoporous structure, suitable pore and particle size and ultralow density. The silica xerogel is loaded with linezolid and capped with epsilon-poly-l-lysine. The developed nano-formulation shows a marked antibacterial activity against to Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. In comparison to free linezolid and epsilon-poly-l-lysine, the material demonstrates a synergistic effect on killing for the three tested bacteria. The results show that silica xerogels can be used as a potential drug carrier and activity enhancer. This strategy could provide the improvement of antibacterial activity spectrum of antibacterial agents like linezolid and could represent a powerful alternative to overcome antibiotic resistance in a near future.
URI: https://doi.org/10.3390/pharmaceutics12111126
https://hdl.handle.net/20.500.13091/687
ISSN: 1999-4923
Appears in Collections:Mühendislik ve Doğa Bilimleri Fakültesi Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collections
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collections
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collections

Files in This Item:
File SizeFormat 
pharmaceutics-12-01126.pdf3.12 MBAdobe PDFView/Open
Show full item record



CORE Recommender

SCOPUSTM   
Citations

8
checked on Mar 23, 2024

WEB OF SCIENCETM
Citations

11
checked on Mar 23, 2024

Page view(s)

156
checked on Mar 25, 2024

Download(s)

34
checked on Mar 25, 2024

Google ScholarTM

Check




Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.