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https://hdl.handle.net/20.500.13091/600
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Filik, Hayati | - |
dc.contributor.author | Avan, Asiye Aslıhan | - |
dc.contributor.author | Puntar, Nilay Altaş | - |
dc.contributor.author | Özyürek, Mustafa | - |
dc.contributor.author | Güngör, Zeynep Banu | - |
dc.contributor.author | Kucur, Mine | - |
dc.contributor.author | Dicle, Diclehan Ali | - |
dc.contributor.author | Kamış, Handan | - |
dc.date.accessioned | 2021-12-13T10:27:01Z | - |
dc.date.available | 2021-12-13T10:27:01Z | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 1572-6657 | - |
dc.identifier.issn | 1873-2569 | - |
dc.identifier.uri | https://doi.org/10.1016/j.jelechem.2021.115700 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.13091/600 | - |
dc.description.abstract | A sensitive sandwich-model immunoassay designed for simultaneous electrochemical measurement of alphafetoprotein and carcinoembryonic antigen handling multiple-label strategy. The sandwich-model immunosensor was constructed by assembling ethylenediamine-MWCNT aerogels (EDA-CAGs), AuNPs and capture antibodies (Cp-Ab1) on the screen-printed carbon electrode (SPCE). The prepared EDA-CAG textures were analyzed using Fourier transform infrared (FT-IR), Scanning Electron Microscopy (SEM) and Energy Dispersive X-Ray Spectroscopy (EDX). In this protocol, AuNPs decorated EDA-CAG-carried Thionine (Thi) and AuNPs decorated EDA-CAG-carried Safranine O (SfO) (denoted as AuNP-Thi-EDA-CAG and AuNP-SfOEDA-CAG, respectively) were properly exploited as distinguishable signal labels, which were used to attach detection antibodies (Ab2) (anti-AFP2 and anti-CEA2), respectively. When two tumor antigens were present, a square wave voltammetry (SWV) scan displayed two well-separated signals, each signal indicated one target antigen. Observed results introduced that the square wave voltammetric peak current exhibited a good linear relationship to logarithm concentration in the ranges from 0.005 to 1.0 ng/mL for both analytes. The LoDs were 0.0015 and 0.0010 ng/mL (at signal/noise S/N = 3) for AFP and CEA, respectively. The designed sandwich-type immunosensor was applied to real serum sample analysis. | en_US |
dc.description.sponsorship | Research Fund of the Istanbul University-Cerrahpasa [FOA-2019-33470] | en_US |
dc.description.sponsorship | This current study was supported by the Research Fund of the Istanbul University-Cerrahpasa (Project ID. FOA-2019-33470). The authors gratefully acknowledge the Istanbul University-Cerrahpasa. | en_US |
dc.language.iso | en | en_US |
dc.publisher | ELSEVIER SCIENCE SA | en_US |
dc.relation.ispartof | JOURNAL OF ELECTROANALYTICAL CHEMISTRY | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Alpha-Fetoprotein | en_US |
dc.subject | Carcinoembryonic Antigen | en_US |
dc.subject | Immunosensor | en_US |
dc.subject | Electrochemistry | en_US |
dc.subject | Serum Analysis | en_US |
dc.subject | Carcinoembryonic Antigen | en_US |
dc.subject | Cancer-Detection | en_US |
dc.subject | 4 Biomarkers | en_US |
dc.subject | Silver | en_US |
dc.subject | Nanocomposites | en_US |
dc.subject | Immunosensors | en_US |
dc.subject | Polymer | en_US |
dc.subject | Lead | en_US |
dc.title | Ethylenediamine grafted carbon nanotube aerogels modified screen-printed electrode for simultaneous electrochemical immunoassay of multiple tumor markers | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1016/j.jelechem.2021.115700 | - |
dc.identifier.scopus | 2-s2.0-85115341035 | en_US |
dc.department | Fakülteler, Mühendislik ve Doğa Bilimleri Fakültesi, Kimya Mühendisliği Bölümü | en_US |
dc.authorid | AVAN, Asiye Aslihan/0000-0002-1654-7647 | - |
dc.authorwosid | AVAN, Asiye Aslihan/D-2187-2019 | - |
dc.identifier.volume | 900 | en_US |
dc.identifier.wos | WOS:000702829200001 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 6602141017 | - |
dc.authorscopusid | 55761557800 | - |
dc.authorscopusid | 57226363370 | - |
dc.authorscopusid | 7801551787 | - |
dc.authorscopusid | 6602676539 | - |
dc.authorscopusid | 18042113100 | - |
dc.authorscopusid | 57189366190 | - |
item.grantfulltext | embargo_20300101 | - |
item.openairetype | Article | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | 02.01. Department of Chemical Engineering | - |
Appears in Collections: | Mühendislik ve Doğa Bilimleri Fakültesi Koleksiyonu Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collections WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collections |
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1-s2.0-S1572665721007268-main.pdf Until 2030-01-01 | 2.72 MB | Adobe PDF | View/Open Request a copy |
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