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https://hdl.handle.net/20.500.13091/4945
Title: | Biopolymeric nanofibrous scaffolds of poly(3-hydroxybuthyrate)/chitosan loaded with biogenic silver nanoparticle synthesized using curcumin and their antibacterial activities | Authors: | Bayram, Sarıipek, F. | Keywords: | Antibacterial activity Biogenic silver nanoparticle Biopolymeric nanofibrous scaffolds Biopolymers Contact angle Drug delivery Escherichia coli Health risks Medical applications Metal nanoparticles Nanofibers Scaffolds Scaffolds (biology) Synthesis (chemical) % reductions Anti-bacterial activity Biogenic silver nanoparticle Biogenics Biopolymeric nanofibrous scaffold Curcumin matrix Nanofibrous scaffolds Synthesised Wound healing Silver nanoparticles biogenic silver nanoparticle biopolymer chitosan chitosan nanoparticle curcumin nanofiber poly(3 hydroxybutyric acid) silver nanoparticle unclassified drug antibacterial activity Article bacterial colonization biopolymeric nanofibrous scaffold contact angle controlled study drug delivery system Escherichia coli field emission scanning electron microscopy Fourier transform mass spectrometry green chemistry hydrophilicity nanofabrication nonhuman particle size Staphylococcus aureus structure analysis synthesis thermogravimetry transmission electron microscopy ultraviolet visible spectrophotometry wettability wound healing X ray diffraction |
Publisher: | Elsevier B.V. | Abstract: | The increasing prevalence of multi-drug resistant bacteria poses a significant threat to public health, especially in wound infections. Developing new bactericidal agents and treatment strategies is crucial to address this issue. In this study, biopolymeric nanofibrous scaffolds containing green-synthesized silver nanoparticles (AgNPs) with curcumin (CUR) were evaluated as antimicrobial materials for wound healing therapy. Firstly, CUR was utilized to synthesize AgNPs, which were then analyzed using various analytical methods. The microstructural analysis revealed that the biogenic AgNPs, which had a spherical shape and an average size of 19.83 nm, were uniformly anchored on PHB/CTS nanofibers. Then, the AgNPs with various content (0.25–1%wt) were incorporated into PHB/CTS matrix to enhance its wettability, thermal and bactericidal behaviors. The nanofibrous scaffolds were characterized by FT-IR, FE-SEM, TGA analysis and water contact angle measurement. Overall, the addition of CUR-AgNPs to the PHB/CTS matrix led to a reduction in fiber diameter, enhanced hydrophilicity and improved thermal properties. Additionally, antibacterial activity against Staphylococcus aureus and Escherichia coli was performed on samples of AgNPS and PHB/CTS/CUR-Ag. The synthesized AgNPs showed antibacterial activity against both microorganisms, especially against S. aureus. Higher concentrations of AgNPs in nanofibers led to a significant reduction in bacterial colony formation. The results displayed that PHB/CTS/CUR-AgNPs nanofibrous scaffolds could be a promising material for the biomedical applications such as wound healing. © 2023 Elsevier B.V. | URI: | https://doi.org/10.1016/j.ijbiomac.2023.128330 https://hdl.handle.net/20.500.13091/4945 |
ISSN: | 0141-8130 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collections Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collections WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collections |
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