Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.13091/3007
Title: Fluorescence switchable sensor enabled by a calix[4]arene-Cu(II) complex system for selective determination of itraconazole in human serum and aqueous solution
Authors: Akceylan, Ezgi
Erdemir, Serkan
Tabakçı, Mustafa
Sivrikaya, Abdullah
Tabakçı, Begüm
Keywords: Pharmaceutical
Itraconazole
Fluorescence sensor
Calixarene
Human serum
Performance Liquid-Chromatography
Mass-Spectrometric Determination
Human Plasma
Fluorometric Detection
Hydroxy Metabolite
Cu(Ii) Ions
Hydroxyitraconazole
Quantitation
Validation
Polymer
Issue Date: 2022
Publisher: Elsevier
Abstract: A switchable fluorescence sensor based on a calix (Monapathi et al., 2021) [4]arene:Cu2+ complex (FLCX/Cu) has been developed for the detection of itraconazole (ITZ) with high sensitivity and specificity. For the devel-opment of the sensor, the selective complexation of a fluorescent calix (Monapathi et al., 2021) [4]arene de-rivative (FL-CX) with the Cu2+ ion causing fluorescence quenching was utilized. In addition, the sensor properties of the FLCX/Cu prepared were investigated. For this purpose, various substances (selected anions, cations, and drugs) with which ITZ can be found together were studied in an aqueous solution. Limit of detection (LOD) and limit of quantification (LOQ) values were determined in the range of 1.00-60.0 mu g/L as 3.34 mu g/L and 11.1 mu g/L for ITZ, respectively. Moreover, the real sample analyses were performed in human serum and tablet form. Furthermore, the effect of some possible serum contents on sensor performance was also studied. All these studies confirmed the development of a simple, precise, accurate, reproducible, highly sensitive, and very stable fluorescence sensor.
URI: https://doi.org/10.1016/j.talanta.2022.123742
https://hdl.handle.net/20.500.13091/3007
ISSN: 0039-9140
1873-3573
Appears in Collections:Mühendislik ve Doğa Bilimleri Fakültesi Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collections
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collections
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collections

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