Please use this identifier to cite or link to this item:
https://hdl.handle.net/20.500.13091/3007
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Akceylan, Ezgi | - |
dc.contributor.author | Erdemir, Serkan | - |
dc.contributor.author | Tabakçı, Mustafa | - |
dc.contributor.author | Sivrikaya, Abdullah | - |
dc.contributor.author | Tabakçı, Begüm | - |
dc.date.accessioned | 2022-10-08T20:50:47Z | - |
dc.date.available | 2022-10-08T20:50:47Z | - |
dc.date.issued | 2022 | - |
dc.identifier.issn | 0039-9140 | - |
dc.identifier.issn | 1873-3573 | - |
dc.identifier.uri | https://doi.org/10.1016/j.talanta.2022.123742 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.13091/3007 | - |
dc.description.abstract | A switchable fluorescence sensor based on a calix (Monapathi et al., 2021) [4]arene:Cu2+ complex (FLCX/Cu) has been developed for the detection of itraconazole (ITZ) with high sensitivity and specificity. For the devel-opment of the sensor, the selective complexation of a fluorescent calix (Monapathi et al., 2021) [4]arene de-rivative (FL-CX) with the Cu2+ ion causing fluorescence quenching was utilized. In addition, the sensor properties of the FLCX/Cu prepared were investigated. For this purpose, various substances (selected anions, cations, and drugs) with which ITZ can be found together were studied in an aqueous solution. Limit of detection (LOD) and limit of quantification (LOQ) values were determined in the range of 1.00-60.0 mu g/L as 3.34 mu g/L and 11.1 mu g/L for ITZ, respectively. Moreover, the real sample analyses were performed in human serum and tablet form. Furthermore, the effect of some possible serum contents on sensor performance was also studied. All these studies confirmed the development of a simple, precise, accurate, reproducible, highly sensitive, and very stable fluorescence sensor. | en_US |
dc.description.sponsorship | Research Foundation of the Selcuk University [21406008] | en_US |
dc.description.sponsorship | We thank the Research Foundation of the Selcuk University (SUBAP- Grant Number 21406008) and for financial support of this work. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.ispartof | Talanta | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Pharmaceutical | en_US |
dc.subject | Itraconazole | en_US |
dc.subject | Fluorescence sensor | en_US |
dc.subject | Calixarene | en_US |
dc.subject | Human serum | en_US |
dc.subject | Performance Liquid-Chromatography | en_US |
dc.subject | Mass-Spectrometric Determination | en_US |
dc.subject | Human Plasma | en_US |
dc.subject | Fluorometric Detection | en_US |
dc.subject | Hydroxy Metabolite | en_US |
dc.subject | Cu(Ii) Ions | en_US |
dc.subject | Hydroxyitraconazole | en_US |
dc.subject | Quantitation | en_US |
dc.subject | Validation | en_US |
dc.subject | Polymer | en_US |
dc.title | Fluorescence switchable sensor enabled by a calix[4]arene-Cu(II) complex system for selective determination of itraconazole in human serum and aqueous solution | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1016/j.talanta.2022.123742 | - |
dc.identifier.pmid | 35858530 | en_US |
dc.identifier.scopus | 2-s2.0-85134427417 | en_US |
dc.department | Fakülteler, Mühendislik ve Doğa Bilimleri Fakültesi, Kimya Mühendisliği Bölümü | en_US |
dc.authorid | Erdemir, Serkan/0000-0003-0790-0549 | - |
dc.authorid | Tabakci, Begum/0000-0003-4735-2882 | - |
dc.authorid | Tabakci, Mustafa/0000-0003-2941-2191 | - |
dc.identifier.volume | 250 | en_US |
dc.identifier.wos | WOS:000831081000002 | en_US |
dc.institutionauthor | Tabakci, Mustafa | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 6504527286 | - |
dc.authorscopusid | 13610351500 | - |
dc.authorscopusid | 6506600394 | - |
dc.authorscopusid | 6508348248 | - |
dc.authorscopusid | 8587997700 | - |
dc.identifier.scopusquality | Q1 | - |
item.languageiso639-1 | en | - |
item.fulltext | With Fulltext | - |
item.cerifentitytype | Publications | - |
item.openairetype | Article | - |
item.grantfulltext | embargo_20300101 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
Appears in Collections: | Mühendislik ve Doğa Bilimleri Fakültesi Koleksiyonu PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collections Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collections WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collections |
Files in This Item:
File | Size | Format | |
---|---|---|---|
1-s2.0-S0039914022005380-main.pdf Until 2030-01-01 | 3.29 MB | Adobe PDF | View/Open Request a copy |
CORE Recommender
WEB OF SCIENCETM
Citations
5
checked on Apr 20, 2024
Page view(s)
178
checked on Apr 22, 2024
Download(s)
6
checked on Apr 22, 2024
Google ScholarTM
Check
Altmetric
Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.