Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.13091/2449
Title: Isolation and characterization of chemical constituents from Chaerophyllum bulbosum roots and their enzyme inhibitory and antioxidant effects
Authors: Tel-Çayan, Gülşen
Deveci, Ebru
Molo, Zeynep
Duru, Mehmet Emin
Öztürk, Mehmet
Keywords: antioxidant effect
C
bulbosum
enzyme inhibitory effect
isolation
roots
Secondary Metabolites
Alpha-Glucosidase
Medicinal-Plants
Phytosterols
Bioactivity
Strategies
Glycosides
Issue Date: 2022
Publisher: Walter De Gruyter Gmbh
Abstract: Isolation and bioactive effects of the roots of Chaerophyllum bulbosum L. were firstly investigated herein. Enzyme (acetylcholinesterase, butyrylcholinesterase, urease, alpha-amylase, alpha-glucosidase, and tyrosinase) inhibitory effects of C. bulbosum root extracts were tested. Three known compounds, n-heptadecanyl eicosanoate (1), stigmasterol (2), and beta-sitosterol-3-O-beta-d-glucopyranoside (3) were isolated from C. bulbosum. Antioxidant and enzyme inhibitory effects of isolated compounds were investigated. The hexane extract (IC50: 349.58 +/- 0.06 mu g/mL) displayed a higher alpha-glucosidase inhibitory effect than the standard (IC50: 378.66 +/- 0.14 mu g/mL). The best inhibitory effect was found in compound 2 on AChE (46.40 +/- 0.31%), BChE (56.41 +/- 0.54%), and urease (92.47 +/- 0.11%); compound 1 on alpha-amylase (22.27 +/- 0.61%); and compound 3 on alpha-glucosidase (12.43 +/- 0.25%) and tyrosinase (19.00 +/- 0.16%). All isolated compounds showed moderate antioxidant effects in all assays. This study contributes to the therapeutic uses of Chaerophyllum roots and emphasizes the value of C. bulbosum species for the development of novel therapeutic agents.
URI: https://doi.org/10.1515/znc-2021-0119
https://hdl.handle.net/20.500.13091/2449
ISSN: 0939-5075
1865-7125
Appears in Collections:Mühendislik ve Doğa Bilimleri Fakültesi Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collections
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collections
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collections

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