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https://hdl.handle.net/20.500.13091/2449
Title: | Isolation and characterization of chemical constituents from Chaerophyllum bulbosum roots and their enzyme inhibitory and antioxidant effects | Authors: | Tel-Çayan, Gülşen Deveci, Ebru Molo, Zeynep Duru, Mehmet Emin Öztürk, Mehmet |
Keywords: | antioxidant effect C bulbosum enzyme inhibitory effect isolation roots Secondary Metabolites Alpha-Glucosidase Medicinal-Plants Phytosterols Bioactivity Strategies Glycosides |
Publisher: | Walter De Gruyter Gmbh | Abstract: | Isolation and bioactive effects of the roots of Chaerophyllum bulbosum L. were firstly investigated herein. Enzyme (acetylcholinesterase, butyrylcholinesterase, urease, alpha-amylase, alpha-glucosidase, and tyrosinase) inhibitory effects of C. bulbosum root extracts were tested. Three known compounds, n-heptadecanyl eicosanoate (1), stigmasterol (2), and beta-sitosterol-3-O-beta-d-glucopyranoside (3) were isolated from C. bulbosum. Antioxidant and enzyme inhibitory effects of isolated compounds were investigated. The hexane extract (IC50: 349.58 +/- 0.06 mu g/mL) displayed a higher alpha-glucosidase inhibitory effect than the standard (IC50: 378.66 +/- 0.14 mu g/mL). The best inhibitory effect was found in compound 2 on AChE (46.40 +/- 0.31%), BChE (56.41 +/- 0.54%), and urease (92.47 +/- 0.11%); compound 1 on alpha-amylase (22.27 +/- 0.61%); and compound 3 on alpha-glucosidase (12.43 +/- 0.25%) and tyrosinase (19.00 +/- 0.16%). All isolated compounds showed moderate antioxidant effects in all assays. This study contributes to the therapeutic uses of Chaerophyllum roots and emphasizes the value of C. bulbosum species for the development of novel therapeutic agents. | URI: | https://doi.org/10.1515/znc-2021-0119 https://hdl.handle.net/20.500.13091/2449 |
ISSN: | 0939-5075 1865-7125 |
Appears in Collections: | Mühendislik ve Doğa Bilimleri Fakültesi Koleksiyonu PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collections Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collections WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collections |
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