Please use this identifier to cite or link to this item:
https://hdl.handle.net/20.500.13091/2449
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Tel-Çayan, Gülşen | - |
dc.contributor.author | Deveci, Ebru | - |
dc.contributor.author | Molo, Zeynep | - |
dc.contributor.author | Duru, Mehmet Emin | - |
dc.contributor.author | Öztürk, Mehmet | - |
dc.date.accessioned | 2022-05-23T20:22:44Z | - |
dc.date.available | 2022-05-23T20:22:44Z | - |
dc.date.issued | 2022 | - |
dc.identifier.issn | 0939-5075 | - |
dc.identifier.issn | 1865-7125 | - |
dc.identifier.uri | https://doi.org/10.1515/znc-2021-0119 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.13091/2449 | - |
dc.description.abstract | Isolation and bioactive effects of the roots of Chaerophyllum bulbosum L. were firstly investigated herein. Enzyme (acetylcholinesterase, butyrylcholinesterase, urease, alpha-amylase, alpha-glucosidase, and tyrosinase) inhibitory effects of C. bulbosum root extracts were tested. Three known compounds, n-heptadecanyl eicosanoate (1), stigmasterol (2), and beta-sitosterol-3-O-beta-d-glucopyranoside (3) were isolated from C. bulbosum. Antioxidant and enzyme inhibitory effects of isolated compounds were investigated. The hexane extract (IC50: 349.58 +/- 0.06 mu g/mL) displayed a higher alpha-glucosidase inhibitory effect than the standard (IC50: 378.66 +/- 0.14 mu g/mL). The best inhibitory effect was found in compound 2 on AChE (46.40 +/- 0.31%), BChE (56.41 +/- 0.54%), and urease (92.47 +/- 0.11%); compound 1 on alpha-amylase (22.27 +/- 0.61%); and compound 3 on alpha-glucosidase (12.43 +/- 0.25%) and tyrosinase (19.00 +/- 0.16%). All isolated compounds showed moderate antioxidant effects in all assays. This study contributes to the therapeutic uses of Chaerophyllum roots and emphasizes the value of C. bulbosum species for the development of novel therapeutic agents. | en_US |
dc.description.sponsorship | Scientific and Technological Research Council of Turkey [TUBITAK-118Z610] | en_US |
dc.description.sponsorship | This study was supported financially by The Scientific and Technological Research Council of Turkey (TUBITAK-118Z610). | en_US |
dc.language.iso | en | en_US |
dc.publisher | Walter De Gruyter Gmbh | en_US |
dc.relation.ispartof | Zeitschrift Fur Naturforschung Section C-A Journal Of Biosciences | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | antioxidant effect | en_US |
dc.subject | C | en_US |
dc.subject | bulbosum | en_US |
dc.subject | enzyme inhibitory effect | en_US |
dc.subject | isolation | en_US |
dc.subject | roots | en_US |
dc.subject | Secondary Metabolites | en_US |
dc.subject | Alpha-Glucosidase | en_US |
dc.subject | Medicinal-Plants | en_US |
dc.subject | Phytosterols | en_US |
dc.subject | Bioactivity | en_US |
dc.subject | Strategies | en_US |
dc.subject | Glycosides | en_US |
dc.title | Isolation and characterization of chemical constituents from Chaerophyllum bulbosum roots and their enzyme inhibitory and antioxidant effects | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1515/znc-2021-0119 | - |
dc.identifier.pmid | 34225392 | en_US |
dc.identifier.scopus | 2-s2.0-85110056696 | en_US |
dc.department | Fakülteler, Mühendislik ve Doğa Bilimleri Fakültesi, Kimya Mühendisliği Bölümü | en_US |
dc.authorid | Tel-Cayan, Gulsen/0000-0002-1916-7391 | - |
dc.identifier.volume | 77 | en_US |
dc.identifier.issue | 1.Şub | en_US |
dc.identifier.startpage | 1 | en_US |
dc.identifier.endpage | 9 | en_US |
dc.identifier.wos | WOS:000744122400001 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.scopusquality | Q3 | - |
item.languageiso639-1 | en | - |
item.fulltext | No Fulltext | - |
item.cerifentitytype | Publications | - |
item.openairetype | Article | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | 07. 04. Department of Chemistry and Chemical Processing Technologies | - |
Appears in Collections: | Mühendislik ve Doğa Bilimleri Fakültesi Koleksiyonu PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collections Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collections WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collections |
CORE Recommender
Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.