Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.13091/1376
Title: Selective chiral recognition of alanine enantiomers by chiral calix[4]arene coated quartz crystal microbalance sensors
Authors: Temel, Farabi
Erdemir, Serkan
Tabakcı, Begüm
Akpınar, Merve
Tabakcı, Mustafa
Keywords: Amino Acid
Calixarene
Alanine
Chiral Recognition
Quartz Crystal Microbalance Sensor
Qcm Sensors
Resonant-Frequency
Discrimination
Immunosensor
Optimization
Interface
Array
Publisher: SPRINGER HEIDELBERG
Abstract: We describe the synthesis of new chiral calix[4]arene derivatives having (R)-1-phenylethylamine, (S)-1-phenylethylamine, (R)-2-phenylglycinol, and (S)-2-phenylglycinol moieties, and chiral recognition studies for enantiomers of some selected -amino acid derivatives such as alanine, phenylalanine, serine, and tryptophan using a quartz crystal microbalance (QCM). Initial experiments indicated that the highest selective chiral recognition factor was 1.42 for alanine enantiomers. The sensitivity, limit of detection, and time constant for l-alanine were calculated as 0.028 Hz/M, 60.9 M, and 36.2 s, respectively. The results indicated that real-time, sensitive, selective, and effective chiral recognition of alanine enantiomers was achieved with a QCM sensor coated with a chiral calix[4]arene derivative having (R)-2-phenylglycinol moieties.
URI: https://doi.org/10.1007/s00216-019-01705-5
https://hdl.handle.net/20.500.13091/1376
ISSN: 1618-2642
1618-2650
Appears in Collections:Mühendislik ve Doğa Bilimleri Fakültesi Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collections
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collections
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collections

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