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https://hdl.handle.net/20.500.13091/4867
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Erci, F. | en_US |
dc.contributor.author | Sarıipek, Fatma Bayram | en_US |
dc.date.accessioned | 2023-12-09T06:55:17Z | - |
dc.date.available | 2023-12-09T06:55:17Z | - |
dc.date.issued | 2023 | en_US |
dc.identifier.issn | 1773-2247 | - |
dc.identifier.uri | https://doi.org/10.1016/j.jddst.2023.105023 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.13091/4867 | - |
dc.description.abstract | In recent years, bioactive natural agent-based wound dressings have gained a lot of interest thanks to their biocompatibility, non-toxicity, and antibacterial properties. In this study, poly(3-hydroxybutyrate)/poly(ε-caprolactone) (PHB/PCL) nanofibrous mats loaded with curcumin-β cyclodextrin (CUR-CD) inclusion complex, a bioactive agent, were successfully developed using the electrospinning technique. First, the CUR-CD inclusion complex was fabricated and characterized by FT-IR, XRD and UV–Vis analyses. This complex was then incorporated into the PHB/PCL nanofibers. The structural, morphological, mechanical, wettability, solubility features and antibacterial activity of the CUR-CD-based PHB/PCL nanofibrous mats were investigated. In addition, the release studies of curcumin (CUR) from the PHB/PCL matrix were performed for each nanofiber composite. FE-SEM results displayed that the fiber diameter was the lowest for PHB/PCL/3%CUR-CD at 392.37 nm compared to the others. According to the results, we observed that adding CUR and CUR-CD improved the thermal stability of PHB/PCL nanofibers. The development of the complex between CUR and βCD was supported by FT-IR analysis. Release test results revealed that the CUR-CD complex contributed to controlled release of CUR from fibers. The plate counting technique was used to examine the antibacterial activity nanofibrous mats. The antibacterial activity of PHB/PCL was significantly enhanced by incorporating the CUR-CD complex, particularly against Gram-positive Staphylococcus aureus. After 6 h of contact, the PHB/PCL/10%CUR-CD nanofiber mat exhibited a remarkable 97.79 % reduction in bacterial growth. The results demonstrated that the fabricated PHB/PCL/CUR-CD nanofibrous mats could be potential candidates for use as a wound dressing. © 2023 | en_US |
dc.description.sponsorship | The authors would like to express their gratitude to Necmettin Erbakan University's Research and Application Center for Science and Technology (BITAM) for their infrastructure. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Editions de Sante | en_US |
dc.relation.ispartof | Journal of Drug Delivery Science and Technology | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Antimicrobial nanofiber | en_US |
dc.subject | Curcumin-cyclodextrin inclusion complex | en_US |
dc.subject | Electrospinning | en_US |
dc.subject | PCL | en_US |
dc.subject | PHB | en_US |
dc.subject | Wound dressing | en_US |
dc.title | Fabrication of antimicrobial poly(3-hydroxybuthyrate)/poly(ε-caprolactone) nanofibrous mats loaded with curcumin/β-cylodextrin inclusion complex as potential wound dressing | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1016/j.jddst.2023.105023 | - |
dc.identifier.scopus | 2-s2.0-85173478822 | en_US |
dc.department | KTÜN | en_US |
dc.identifier.volume | 89 | en_US |
dc.identifier.wos | WOS:001100007100001 | en_US |
dc.institutionauthor | … | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 56708760300 | - |
dc.authorscopusid | 57729233200 | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | Article | - |
crisitem.author.dept | 02.01. Department of Chemical Engineering | - |
Appears in Collections: | Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collections WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collections |
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