Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.13091/455
Title: Antioxidant, Cytotoxic, and Enzyme Inhibitory Activities of Agropyron repens and Crataegus monogyna Species
Authors: Deveci, Ebru
Çayan, Gülşen Tel
Karakurt, Serdar
Duru, Mehmet Emin
Issue Date: 2020
Abstract: Objective: The aim of this study was to investigate antioxidant, enzyme inhibitory and cytotoxic activities of Agropyron repens and Crataegus monogyna methanol extracts with total phenolic and flavonoid contents. Materials and Methods: Total phenolic and flavonoid contents of A. repens and C. monogyna methanol extracts were measured according to Folin Ciocalteu and aluminum nitrate methods, respectively. Antioxidant and enzyme inhibitory activities of the methanol extracts were tested spectrophotometrically. Also, cytotoxic activities of the methanol extracts against DLD-1 and CCD-18Co were investigated by using Alamar Blue assay. Results: C. monogyna methanol extract with the highest total phenolic and flavonoid contents (68.13±0.34 µg GAEs/mg extract and 36.91±0.17 µg QEs/mg extract, respectively) had the best antioxidant activity in ?-carotene-linoleic acid ($IC_50$: 32.72±0.15 µg/mL), CUPRAC ($A_0.50$: 282.69±0.25 µg/mL), DPPH• ($IC_50$: 71.69±0.85 µg/mL), and ABTS•+ ($IC_50$: 40.43±0.55 µg/ mL) assays. A. repens methanol extract showed the highest effect against AChE (18.73±0.47 %), BChE (37.59±1.07 %), urease (89.18±0.84%), ?-glucosidase (6.71±0.23 %), whereas C. monogyna methanol extract showed the highest effect against tyrosinase (30.52±1.00%) and ?-amylase (37.24±0.06 %). Also, A. repens ($IC_50$: 57.38 µg/mL) and C. monogyna ($IC_50$: 54.04 µg/ mL) methanol extracts showed close cytotoxic activity on DLD-1. Conclusion: Antioxidant, cytotoxic, and enzyme inhibitory activities of A. repens and C. monogyna methanol extracts were investigated with total phenolic and flavonoid contents in this study. The results obtained with this study strengthen the potential of the studied plants as a new source for the discovery of antioxidant, cytotoxic, and enzyme inhibitor agents.
URI: https://doi.org/10.26650/EurJBiol.2020.0077
https://app.trdizin.gov.tr/makale/TkRZeE9UZzFOUT09
https://hdl.handle.net/20.500.13091/455
ISSN: 2602-2575
2618-6144
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collections
Teknik Bilimler Meslek Yüksekokulu Koleskiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collections

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