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Title: Inhibitory activities of medicinal mushrooms on alpha-amylase and alpha-glucosidase-enzymes related to type 2 diabetes
Authors: Deveci, Ebru
Çayan, Fatih
Çayan, Gülsen Tel
Duru, Mehmet Emin
Keywords: Type 2 Diabetes
Antidiabetic Properties
Issue Date: 2021
Publisher: ELSEVIER
Abstract: Mushrooms have been used as a primary source of medicines since ancient times due to the presence of bioactive compounds. Enzyme inhibition is an important field of pharmaceutical research that provides insight into the discovery of a large variety of drugs that are useful in treating many diseases. The inhibitory activities of the hexane and methanol extracts of twenty-four medicinal mushrooms on alpha-amylase and alpha-glucosidase enzymes related to type 2 diabetes were evaluated in this study. Among all studied mushroom extracts, C. rutilus hexane extract (IC50: 0.05 +/- 0.01 mg/mL) demonstrated the highest inhibitory activity on alpha-amylase while P. ostreatus hexane (IC50: 0.10 +/- 0.01 mg/mL) showed the highest inhibitory activity on alpha-glucosidase. The hexane extracts of C. rutilus (98.81 +/- 0.01 %), G. adspersum (96.96 +/- 0.47 %), G. sepiarium (96.89 +/- 1.01 %), and S. granulatus (97.74 +/- 0.27 %) displayed higher inhibitory activity on alpha-amylase enzyme than acarbose at 1.00 mg/mL concentration. Also, the hexane extracts of P. ostreatus (IC50: 0.10 +/- 0.01 mg/mL), M. procera (IC50: 0.11 +/- 0.01 mg/mL), P. schweinitzii (IC50: 0.14 +/- 0.01 mg/mL), L. gentianeus (IC50: 0.22 +/- 0.02 mg/mL), P. pini (IC50: 0.22 +/- 0.03 mg/mL) and the methanol extracts of T. pubescens (IC50: 0.12 +/- 0.02 mg/mL) and G. adspersum (IC50: 0.20 +/- 0.04 mg/mL) showed higher inhibitory activity on alpha-glucosidase enzyme than acarbose (IC50: 0.37 +/- 0.01 mg/mL). This study with the reported results supported the use of mushrooms in the pharmaceutical industries as natural antidiabetic agents through key enzyme inhibition. (C) 2020 SAAB. Published by Elsevier B.V. All rights reserved.
ISSN: 0254-6299
Appears in Collections:Mühendislik ve Doğa Bilimleri Fakültesi Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collections
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collections

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