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https://hdl.handle.net/20.500.13091/340
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DC Field | Value | Language |
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dc.contributor.author | Çayan, Fatih | - |
dc.contributor.author | Çayan, Gülsen Tel | - |
dc.contributor.author | Deveci, Ebru | - |
dc.contributor.author | Duru, Mehmet Emin | - |
dc.contributor.author | Türk, Mustafa | - |
dc.date.accessioned | 2021-12-13T10:24:03Z | - |
dc.date.available | 2021-12-13T10:24:03Z | - |
dc.date.issued | 2022 | - |
dc.identifier.issn | 0950-5423 | - |
dc.identifier.issn | 1365-2621 | - |
dc.identifier.uri | https://doi.org/10.1111/ijfs.15190 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.13091/340 | - |
dc.description.abstract | Mushrooms and truffles are attracting attention as a new generation of biotherapeutics. In the current study, isolation, phenolic and organic acid composition, and antioxidant, cytotoxic, anticholinesterase activities of truffle Reddellomyces parvulosporus were examined. Four known compounds (brassicasterol (1), ergosterol peroxide (2), fumaric acid (3) and mannitol (4)) were isolated with the combination of chromatographic techniques. Fumaric acid (54.74 +/- 0.85 mu g g(-1)) was found as the major compound by HPLC-DAD. All isolated compounds were bioassayed for antioxidant, cytotoxic, anticholinesterase, anti-tyrosinase, anti-urease, anti-alpha-glucosidase and anti-alpha-amylase activities. Compound 1 indicated notable cytotoxic activity on MCF-7 (IC50: 38.08 +/- 0.75 mu g mL(-1)) and compound 3 on H1299 (IC50: 62.37 +/- 0.75 mu g mL(-1)). Also, compounds 1 (84.55 +/- 1.14%) and 2 (84.90 +/- 0.10%) showed higher anti-urease activity than thiourea (78.57 +/- 0.22%), while compound 2 (66.31 +/- 0.08%) displayed near-standard anti-BChE activity. Also, being the first to emphasise the potential of R. parvulosporus as a natural food additive, this study evidenced its medicinal importance by revealing bioactive compounds and properties. | en_US |
dc.description.sponsorship | Scientific and Technological Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [TUBITAK-114Z644] | en_US |
dc.description.sponsorship | This study is a part of F.C.'s PhD thesis. The authors would like to thank to The Scientific and Technological Research Council of Turkey (Project number: TUBITAK-114Z644) for the financial support. | en_US |
dc.language.iso | en | en_US |
dc.publisher | WILEY | en_US |
dc.relation.ispartof | INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Antioxidant Activity | en_US |
dc.subject | Cytotoxic Activity | en_US |
dc.subject | Enzyme Inhibitory Activity | en_US |
dc.subject | Isolation | en_US |
dc.subject | Mushroom | en_US |
dc.subject | R | en_US |
dc.subject | Parvulosporus | en_US |
dc.subject | Truffle | en_US |
dc.subject | Chemical-Constituents | en_US |
dc.subject | Medicinal Mushrooms | en_US |
dc.subject | Antioxidant | en_US |
dc.subject | Anticancer | en_US |
dc.subject | Glucosidase | en_US |
dc.subject | Inhibition | en_US |
dc.subject | Mannitol | en_US |
dc.subject | Amylase | en_US |
dc.subject | Fungi | en_US |
dc.title | A detailed study on multifaceted bioactivities of the extracts and isolated compounds from truffle Reddellomyces parvulosporus | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1111/ijfs.15190 | - |
dc.identifier.scopus | 2-s2.0-85107921165 | en_US |
dc.department | Fakülteler, Mühendislik ve Doğa Bilimleri Fakültesi, Kimya Mühendisliği Bölümü | en_US |
dc.authorid | Tel-Cayan, Gulsen/0000-0002-1916-7391 | - |
dc.authorwosid | DURU, Mehmet Emin/ABA-2426-2021 | - |
dc.identifier.wos | WOS:000661906500001 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 56005323200 | - |
dc.authorscopusid | 57194732739 | - |
dc.authorscopusid | 56089358000 | - |
dc.authorscopusid | 12789661400 | - |
dc.authorscopusid | 8920503400 | - |
dc.identifier.scopusquality | Q1 | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | Article | - |
item.grantfulltext | embargo_20300101 | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | 07. 04. Department of Chemistry and Chemical Processing Technologies | - |
Appears in Collections: | Mühendislik ve Doğa Bilimleri Fakültesi Koleksiyonu Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collections WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collections |
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Int J of Food Sci Tech - 2021 - ayan - A detailed study on multifaceted bioactivities of the extracts and isolated.pdf Until 2030-01-01 | 197.82 kB | Adobe PDF | View/Open Request a copy |
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