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https://hdl.handle.net/20.500.13091/3008
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DC Field | Value | Language |
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dc.contributor.author | Çayan, Fatih | - |
dc.contributor.author | Tel-Çayan, Gülsen | - |
dc.contributor.author | Deveci, Ebru | - |
dc.contributor.author | Duru, Mehmet Emin | - |
dc.contributor.author | Öztürk, Mehmet | - |
dc.date.accessioned | 2022-10-08T20:50:47Z | - |
dc.date.available | 2022-10-08T20:50:47Z | - |
dc.date.issued | 2022 | - |
dc.identifier.issn | 1359-5113 | - |
dc.identifier.uri | https://doi.org/10.1016/j.procbio.2022.08.001 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.13091/3008 | - |
dc.description.abstract | Truffles have become one of the world's most important mushrooms owing to their distinctive features. To the best of our knowledge, this is the first study on Reddellomyces westraliensis in terms of isolation and identification of compounds and screening versatile bioactivities. Chromatographic studies on R. westraliensis enabled to isolate brassicasterol (1), ergosta-7,9,22-trien-3?-ol (2), ergosterol peroxide (3), adenosine (4), D-ribitol (5), fumaric acid (6) and mannitol (7). The structures of the compounds were verified by IR, NMR, MS techniques. Antioxidant, cytotoxic and cholinesterase, tyrosinase, urease, ?-amylase and ?-glucosidase inhibitory activities were assessed. The methanol was the suitable extraction solvent high content of phenolic compound (18.94 ± 0.18 ?g PEs/mg extract). Compound 4 showed higher DPPH• (IC50: 8.38 ± 0.40 µg/mL) and ABTS•+ (IC50: 6.74 ± 0.22 µg/mL) scavenging activity than ?-tocopherol and BHA. Compound 3 was observed as a potent inhibitor against AChE (34.03 ± 0.13 %), ?-amylase (34.28 ± 0.36 %) and BChE (66.31 ± 0.08 %). Compounds 1 (IC50: 5.85 ± 0.16 µg/mL) and 3 (IC50: 6.98 ± 0.24 µg/mL) indicated higher urease inhibitory activity than thiourea (IC50: 7.87 ± 0.18 µg/mL). Compounds 4 (9.61 ± 0.92 %) and 7 (21.56 ± 0.74 %) indicated higher ?-glucosidase and tyrosinase inhibitory activity, respectively. Compound 2 exhibited the best cytotoxicity against H1299 (IC50: 38.62 ± 0.46 µg/mL) and MCF-7 (IC50: 24.93 ± 0.80 µg/mL). HPLC-DAD analysis exhibited the existence of fumaric acid (27.20 ± 0.06 µg/g) as the major compound. This study revealed that R. westraliensis can be approved as antioxidant, cytotoxic, and enzyme inhibitor sources in conjunction with its varied bioactive compounds. © 2022 Elsevier Ltd | en_US |
dc.description.sponsorship | Türkiye Bilimsel ve Teknolojik Araştırma Kurumu, TÜBİTAK: TUBITAK?114Z644 | en_US |
dc.description.sponsorship | This study is a part of F.Ç.’s Ph.D. thesis. The authors are deeply indebted to The Scientific and Technological Research Council of Turkey (Project number: TUBITAK?114Z644) for the opportunity to carry out this research. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier Ltd | en_US |
dc.relation.ispartof | Process Biochemistry | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Antioxidant activity | en_US |
dc.subject | Cytotoxic activity | en_US |
dc.subject | Enzyme inhibitory activity | en_US |
dc.subject | Isolation | en_US |
dc.subject | R. westraliensis | en_US |
dc.subject | Alcohols | en_US |
dc.subject | Amylases | en_US |
dc.subject | Bioactivity | en_US |
dc.subject | Enzyme activity | en_US |
dc.subject | Organic solvents | en_US |
dc.subject | Antioxidant activities | en_US |
dc.subject | Cytotoxic | en_US |
dc.subject | Cytotoxic activities | en_US |
dc.subject | Enzyme inhibitory activity | en_US |
dc.subject | Fumaric acids | en_US |
dc.subject | Glucosidase | en_US |
dc.subject | Inhibitory activity | en_US |
dc.subject | Isolation | en_US |
dc.subject | Isolation and identification | en_US |
dc.subject | R westraliensis | en_US |
dc.subject | Antioxidants | en_US |
dc.title | Isolation and identification of compounds from truffle Reddellomyces westraliensis and their antioxidant, cytotoxic and enzyme inhibitory activities | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1016/j.procbio.2022.08.001 | - |
dc.identifier.scopus | 2-s2.0-85135723786 | en_US |
dc.department | Fakülteler, Mühendislik ve Doğa Bilimleri Fakültesi, Kimya Mühendisliği Bölümü | en_US |
dc.identifier.volume | 121 | en_US |
dc.identifier.startpage | 553 | en_US |
dc.identifier.endpage | 562 | en_US |
dc.identifier.wos | WOS:000860682500007 | en_US |
dc.institutionauthor | Deveci, Ebru | - |
dc.institutionauthor | Duru, Mehmet Emin | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 56005323200 | - |
dc.authorscopusid | 57743199000 | - |
dc.authorscopusid | 56089358000 | - |
dc.authorscopusid | 12789661400 | - |
dc.authorscopusid | 7102665882 | - |
dc.identifier.scopusquality | Q2 | - |
item.languageiso639-1 | en | - |
item.fulltext | With Fulltext | - |
item.cerifentitytype | Publications | - |
item.openairetype | Article | - |
item.grantfulltext | embargo_20300101 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | 07. 04. Department of Chemistry and Chemical Processing Technologies | - |
Appears in Collections: | Mühendislik ve Doğa Bilimleri Fakültesi Koleksiyonu Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collections WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collections |
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1-s2.0-S1359511322002847-main.pdf Until 2030-01-01 | 1.72 MB | Adobe PDF | View/Open Request a copy |
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