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https://hdl.handle.net/20.500.13091/2897
Title: | Preparation of poly(?-caprolactone) nanofibrous mats incorporating graphene oxide-silver nanoparticle hybrid composite by electrospinning method for potential antibacterial applications | Authors: | Sarıipek, Fatma Bayram Sevgi, Fatih Dursun, Sami |
Keywords: | Antibacterial activity Electrospinning method Graphene oxide-silver nanoparticle Hybrid nanocomposites Polycaprolactone Electrospinning Escherichia coli Graphene Medical applications Metal ions Metal nanoparticles Nanocomposites Nanofibers Synthesis (chemical) Tensile strength Anti-bacterial activity Antibacterials Electrospinning method Graphene oxide-silver nanoparticle Graphene oxides Hybrid composites Hybrid nanocomposites Nano-fibrous Poly(? caprolactone) Synthesised Silver nanoparticles clarithromycin graphene oxide polycaprolactone silver nanoparticle absorption spectroscopy antibacterial activity Article atomic absorption spectrometry bacterial membrane bacteriostatic activity bacterium adherence contact angle controlled study disk diffusion drug conjugation drug potentiation electrospinning Escherichia coli field emission scanning electron microscopy Fourier transform infrared spectroscopy high resolution transmission electron microscopy hydrophilicity microbial adhesion nanofabrication nonhuman oxidative stress Staphylococcus aureus surface area surface plasmon resonance surface property tensile strength ultraviolet spectroscopy wettability |
Publisher: | Elsevier B.V. | Abstract: | In this study, poly(?-caprolactone) based fibrous mats incorporating graphene oxide-silver hybrid nanocomposite as a nanofiller were successfully prepared by electrospinning method for potential biomedical applications. First, graphene oxide-silver nanoparticles (GO-AgNPs) were synthesized and the obtained GO-AgNPs nanohybrid was characterized by different analytical techniques. It was observed that the obtained AgNPs, with an average size of 5 ± 0.5 nm and spherical shape, were uniformly anchored on the surface of GO. Then, the synthesized GO-AgNPs were added into PCL to improve its tensile and bactericidal performances. The structural, morphological, mechanical and wettability properties of PCL-based fibrous mats as well as the release of silver ion release from PCL matrix were examined. Based on the results, we found that the addition of GO to the PCL-3.0%Ag nanofibers resulted in increased hydrophilicity, tensile strength and resistance to elastic deformation, and the PCL-GO-3.0%Ag sample also had a significantly higher release of silver ions. Besides, PCL-GO–3.0%Ag mats showed good antibacterial activity against Staphylococcus aureus and Escherichia coli compared to the PCL, PCL-GO and PCL-Ag nanofibrous mats. In summary, this study showed that PCL-GO–3.0%Ag nanofibrous mats could be a promising biomaterial for potential antibacterial applications. © 2022 Elsevier B.V. | URI: | https://doi.org/10.1016/j.colsurfa.2022.129969 https://hdl.handle.net/20.500.13091/2897 |
ISSN: | 0927-7757 |
Appears in Collections: | Mühendislik ve Doğa Bilimleri Fakültesi Koleksiyonu Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collections WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collections |
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1-s2.0-S0927775722017241-main.pdf Until 2030-01-01 | 10.31 MB | Adobe PDF | View/Open Request a copy |
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