Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.13091/2897
Title: Preparation of poly(?-caprolactone) nanofibrous mats incorporating graphene oxide-silver nanoparticle hybrid composite by electrospinning method for potential antibacterial applications
Authors: Sarıipek, Fatma Bayram
Sevgi, Fatih
Dursun, Sami
Keywords: Antibacterial activity
Electrospinning method
Graphene oxide-silver nanoparticle
Hybrid nanocomposites
Polycaprolactone
Electrospinning
Escherichia coli
Graphene
Medical applications
Metal ions
Metal nanoparticles
Nanocomposites
Nanofibers
Synthesis (chemical)
Tensile strength
Anti-bacterial activity
Antibacterials
Electrospinning method
Graphene oxide-silver nanoparticle
Graphene oxides
Hybrid composites
Hybrid nanocomposites
Nano-fibrous
Poly(? caprolactone)
Synthesised
Silver nanoparticles
clarithromycin
graphene oxide
polycaprolactone
silver nanoparticle
absorption spectroscopy
antibacterial activity
Article
atomic absorption spectrometry
bacterial membrane
bacteriostatic activity
bacterium adherence
contact angle
controlled study
disk diffusion
drug conjugation
drug potentiation
electrospinning
Escherichia coli
field emission scanning electron microscopy
Fourier transform infrared spectroscopy
high resolution transmission electron microscopy
hydrophilicity
microbial adhesion
nanofabrication
nonhuman
oxidative stress
Staphylococcus aureus
surface area
surface plasmon resonance
surface property
tensile strength
ultraviolet spectroscopy
wettability
Issue Date: 2022
Publisher: Elsevier B.V.
Abstract: In this study, poly(?-caprolactone) based fibrous mats incorporating graphene oxide-silver hybrid nanocomposite as a nanofiller were successfully prepared by electrospinning method for potential biomedical applications. First, graphene oxide-silver nanoparticles (GO-AgNPs) were synthesized and the obtained GO-AgNPs nanohybrid was characterized by different analytical techniques. It was observed that the obtained AgNPs, with an average size of 5 ± 0.5 nm and spherical shape, were uniformly anchored on the surface of GO. Then, the synthesized GO-AgNPs were added into PCL to improve its tensile and bactericidal performances. The structural, morphological, mechanical and wettability properties of PCL-based fibrous mats as well as the release of silver ion release from PCL matrix were examined. Based on the results, we found that the addition of GO to the PCL-3.0%Ag nanofibers resulted in increased hydrophilicity, tensile strength and resistance to elastic deformation, and the PCL-GO-3.0%Ag sample also had a significantly higher release of silver ions. Besides, PCL-GO–3.0%Ag mats showed good antibacterial activity against Staphylococcus aureus and Escherichia coli compared to the PCL, PCL-GO and PCL-Ag nanofibrous mats. In summary, this study showed that PCL-GO–3.0%Ag nanofibrous mats could be a promising biomaterial for potential antibacterial applications. © 2022 Elsevier B.V.
URI: https://doi.org/10.1016/j.colsurfa.2022.129969
https://hdl.handle.net/20.500.13091/2897
ISSN: 0927-7757
Appears in Collections:Mühendislik ve Doğa Bilimleri Fakültesi Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collections
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collections

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