Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.13091/2505
Title: HPLC-DAD characterization of phenolic profile and in vitro antioxidant, anticholinesterase, and antidiabetic activities of five mushroom species from Turkey
Authors: Çayan, Fatih
Tel-Çayan, Gülşen
Deveci, Ebru
Duru, Mehmet Emin
Keywords: Mushroom species
Phenolic compounds
Antioxidant activity
Anticholinesterase activity
Antidiabetic activity
Alpha-Glucosidase
Medicinal Mushrooms
Amylase
Acetylcholinesterase
Inhibitors
Extracts
Publisher: Springer Heidelberg
Abstract: In this study, Daedalea quercina (L.) Pers., Hydnum repandum L., Inonotus radiatus (Sowerby) P. Karst., Omphalotus olearius (DC.) Singer, and Schizophyllum commune Fr. hexane and methanol extracts were subjected to the spectrophotometric assays for antioxidant and enzyme inhibitory activities, which are linked with human diseases that are very prevalent in recent years. Additionally, phenolic compounds of the mushrooms were quantified by HPLC-DAD. The best antioxidant activity was found in H. repandum methanol extract (IC50: 12.04 +/- 0.24 mu g/mL) in the beta -carotene-linoleic assay; I. radiatus methanol extract in DPPH center dot (81.22 +/- 0.50%), ABTS(center dot+) (IC50: 73.47 +/- 0.18 mu g/mL), and CUPRAC (A(0.50): 88.21 +/- 0.02 mu g/mL) assays; S. commune hexane extract (53.36 +/- 0.89%) in the metal chelating assay. O. olearius hexane extract was found as the best inhibitor against AChE (71.58 +/- 0.28%) and BChE (67.30 +/- 0.15%). When I. radiatus methanol (95.88 +/- 0.74%) and H. repandum hexane (95.75 +/- 0.16%) extracts showed close alpha -amylase inhibitory activity to acarbose (96.68 +/- 0.08%), D. quercina methanol extract (70.79 +/- 0.34%) had higher alpha -glucosidase inhibitory activity than acarbose (67.01 +/- 2.28%). Among 16 phenolic compounds analyzed, gallic acid (0.02 +/- 0.01-0.23 +/- 0.01 mu g/g) was detected in all studied mushrooms. This study provides that investigated mushrooms can be used for further research, which can lead to the development of new natural remedies to alleviate complications related to oxidative stress, diabetes, and neurological diseases.
URI: https://doi.org/10.1007/s13205-021-02819-3
https://hdl.handle.net/20.500.13091/2505
ISSN: 2190-572X
2190-5738
Appears in Collections:Mühendislik ve Doğa Bilimleri Fakültesi Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collections
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collections
Teknik Bilimler Meslek Yüksekokulu Koleskiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collections

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