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https://hdl.handle.net/20.500.13091/2467
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yıldırım, Şeküre | - |
dc.contributor.author | Akyıldız, Hasan | - |
dc.contributor.author | Çetinkaya, Zeynep | - |
dc.date.accessioned | 2022-05-23T20:23:40Z | - |
dc.date.available | 2022-05-23T20:23:40Z | - |
dc.date.issued | 2022 | - |
dc.identifier.issn | 1318-0207 | - |
dc.identifier.issn | 1580-3155 | - |
dc.identifier.uri | https://doi.org/10.17344/acsi.2021.6838 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.13091/2467 | - |
dc.description.abstract | In this study, it is aimed to develop glucose/fructose sensitive poly(ethylene glycol) methyl ether methacrylate (PEGMA) particles which can be employed in controlled drug delivery applications. For this purpose, a boric acid based crosslinker was synthesized using 4-vinylphenylboronic acid (VPBA) and its formation was confirmed by H-1-NMR and FT-IR analyses. Sugar-sensitive polymeric particles were then achieved using this crosslinker and PEGMA monomer in single step and surfactant free emulsion polymerization technique. Polymeric particles were characterized by DLS, SEM, and TEM in terms of size and morphology. In order to determine the sensitivity of the particles to sugar molecules, first Rhodamine B dye (as a model drug) loading experiments were performed. Then, the particles were subjected to glucose/fructose rich media and dye release was monitored as a function of time using UV-Vis spectrophotometry. The results of the current study revealed that the PEGMA particles were more sensitive to fructose (similar to 39% release) compared to glucose (similar to 25% release) at pH 7.4 and 310 K. | en_US |
dc.description.sponsorship | Scientific Research Foundation (BAP) of Selcuk University [191019020] | en_US |
dc.description.sponsorship | Support for this work is provided by the Scientific Research Foundation (BAP) of Selcuk University (Project Number 191019020) which authors gratefully acknowledge. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Slovensko Kemijsko Drustvo | en_US |
dc.relation.ispartof | Acta Chimica Slovenica | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Controlled drug release | en_US |
dc.subject | fructose sensitivity | en_US |
dc.subject | phenylboronic acid | en_US |
dc.subject | smart polymers | en_US |
dc.subject | crosslinker | en_US |
dc.subject | Covalent Organic Framework | en_US |
dc.subject | Phenylboronic Acid | en_US |
dc.subject | Polymer Complex | en_US |
dc.subject | Nanoparticles | en_US |
dc.subject | Crystalline | en_US |
dc.subject | Electron | en_US |
dc.subject | Ph | en_US |
dc.title | Synthesis of Glucose/Fructose Sensitive Poly(ethylene glycol) Methyl Ether Methacrylate Particles with Novel Boronate Ester Bridge Crosslinker and their Dye Release Applications | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.17344/acsi.2021.6838 | - |
dc.identifier.pmid | 35298009 | en_US |
dc.identifier.scopus | 2-s2.0-85126675118 | en_US |
dc.department | Fakülteler, Mühendislik ve Doğa Bilimleri Fakültesi, Metalurji ve Malzeme Mühendisliği Bölümü | en_US |
dc.identifier.volume | 69 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | 39 | en_US |
dc.identifier.endpage | 48 | en_US |
dc.identifier.wos | WOS:000779953600004 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.scopusquality | Q3 | - |
item.grantfulltext | embargo_20300101 | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.openairetype | Article | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | 02.11. Department of Metallurgical and Materials Engineering | - |
crisitem.author.dept | 02.11. Department of Metallurgical and Materials Engineering | - |
Appears in Collections: | Mühendislik ve Doğa Bilimleri Fakültesi Koleksiyonu PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collections Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collections WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collections |
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s13369-022-06883-6.pdf Until 2030-01-01 | 4.87 MB | Adobe PDF | View/Open Request a copy |
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