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https://hdl.handle.net/20.500.13091/1741
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DC Field | Value | Language |
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dc.contributor.author | Durmuş, İrem M. | - |
dc.contributor.author | Deveci, İlyas | - |
dc.contributor.author | Karakurt, Serdar | - |
dc.date.accessioned | 2022-01-30T17:32:59Z | - |
dc.date.available | 2022-01-30T17:32:59Z | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 1871-5206 | - |
dc.identifier.issn | 1875-5992 | - |
dc.identifier.uri | https://doi.org/10.2174/1871520621666210208105521 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.13091/1741 | - |
dc.description.abstract | Background: Prostate cancer (PCa) has the second-highest morbidity and mortality rates in men. Possessing facile surface chemistry and unique optical properties make silica nanoparticles(SiO2-NPs) promising cancer therapy materials. Objective: This study aimed to investigate the effects of SiO2-NPs and their derivatives, including SiNP-NH2, SiNP-Cl, and SiNP-SH against PCa and clarify their molecular mechanism on cell death, gene, and protein expressions. Methods: Following the synthesis and derivation of SiO2-NPs, their characterization was carried out using TEM, DLS, BET, and FT-IR. Cytotoxic properties of the compounds were investigated against different human cancerous cells; including HUH-7, A549, DLD-1, HeLa, NCI-H295R, and PC-3, as well as human healthy epithelium cell line PNT1A. Results: SiNP-NH2, SiNP-Cl, and SiNP-SH dose-dependently inhibited the proliferation of PC-3 cells with an IC50 value as 55.46 mu g/mL, 55.09 mu g/mL and 72.89 mu g/mL, respectively. SiNP-SH significantly(p<0.0001) inhibited metastasis and invasion of PC-3 cells(20.4% and 46.7%, respectively), and significantly(p<0.0001) increased early apoptosis(32.3%) when compared with non-treated cells. Protein and mRNA expressions of BcL-2, Bax, caspase-3, caspase-9, caspase-12, p53, Smad-4, Kras, and Nf-kappa B were also altered following the treatment of SiO2-NPs and its derivatives. Conclusion: Our results demonstrated that-SH functioned SiO2-NPs can prevent the proliferation of human PCa by increasing apoptosis by up-regulating gene and protein expression of p53(TP53) as well as caspase-3, caspase-9, and caspase-12 in the apoptotic pathway. Besides, the increased level of Smad-4 has also implicated the decreased cell proliferation. Hence, low sized SiNP-SH nanoparticles might be a suitable candidate for the treatment of human PCa. | en_US |
dc.description.sponsorship | Research Foundation of Selcuk UniversitySelcuk University [19201089] | en_US |
dc.description.sponsorship | We would like to thank the Research Foundation of Selcuk University [grant number 19201089] . | en_US |
dc.language.iso | en | en_US |
dc.publisher | Bentham Science Publ Ltd | en_US |
dc.relation.ispartof | Anti-Cancer Agents In Medicinal Chemistry | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Silica Nanoparticles | en_US |
dc.subject | Cytotoxicity | en_US |
dc.subject | Prostate Cancer | en_US |
dc.subject | Metastasis | en_US |
dc.subject | Apoptosis | en_US |
dc.subject | Gene | en_US |
dc.subject | Protein Expression | en_US |
dc.subject | Acid | en_US |
dc.subject | Expression | en_US |
dc.subject | Gold | en_US |
dc.title | Synthesis of Silica Based Nanoparticles Against the Proliferation of Human Prostate Cancer | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.2174/1871520621666210208105521 | - |
dc.identifier.pmid | 33557739 | en_US |
dc.identifier.scopus | 2-s2.0-85121515853 | en_US |
dc.department | Meslek Yüksekokulları, Teknik Bilimler Meslek Yüksekokulu, Kimya ve Kimyasal İşleme Teknolojileri Bölümü | en_US |
dc.authorid | DURMUS, IREM MUKADDES/0000-0002-3162-8381 | - |
dc.identifier.volume | 21 | en_US |
dc.identifier.issue | 18 | en_US |
dc.identifier.startpage | 2553 | en_US |
dc.identifier.endpage | 2562 | en_US |
dc.identifier.wos | WOS:000735422800010 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 57316343400 | - |
dc.authorscopusid | 35955890400 | - |
dc.authorscopusid | 47561434400 | - |
dc.identifier.scopusquality | Q3 | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.languageiso639-1 | en | - |
item.openairetype | Article | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | 07. 04. Department of Chemistry and Chemical Processing Technologies | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collections Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collections WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collections |
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