Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.13091/1372
Title: Real-time and selective recognition of erythromycin by self-assembly of calix[4]arene on QCM sensor
Authors: Temel, Farabi
Keywords: Calixarene
Erythromycin
Quartz Crystal Microbalance Sensor
Self-Assembled Monolayer
Sensitivity
Liquid-Chromatography
Rat Plasma
Biosensor
Antibiotics
Surface
Acid
Immunosensor
Calixarenes
Adsorption
Extraction
Publisher: ELSEVIER
Abstract: This paper describes the synthesis of an amino morpholine-based the new schiff base calix[4]arene (compound 5), it's coating on Quartz Crystal Microbalance (QCM) crystal as a self-assembled monolayer (SAM), and real-time detection of erythromycin (ERY) in aqueous media. The characterization of the QCM sensor has been succeeded with atomic force microscopy and contact angle measurements. Initial experiments revealed that the frequency response decreased quickly as expected and reached equilibrium within 5 min which means that there was a good interaction between the compound 5 coated QCM sensor surface and ERY molecules. The QCM sensor showed a linear response towards ERY solutions in different concentrations ranging from 10 to 200 mu M, with the sensitivity (S) and limit of detection (LOD) being 0.66 Hz/NM and 4.80 NM, respectively. Furthermore, the adsorption behavior and mechanism of ERY onto the QCM sensor were applied for this sensing system and the adsorption data exhibited a good correlation with the Langmuir adsorption isotherm in terms of R-2 and Delta m(max). The QCM sensor was shown outstanding selective performance to ERY among some biologic molecules such as amino add, drug, hormone, vitamin. Thus, real-time, sensitive, selective and effective recognition of ERY was performed by a calixarene derivative coated QCM sensor. (C) 2019 Elsevier B.V. All rights reserved.
URI: https://doi.org/10.1016/j.molliq.2019.111818
https://hdl.handle.net/20.500.13091/1372
ISSN: 0167-7322
1873-3166
Appears in Collections:Mühendislik ve Doğa Bilimleri Fakültesi Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collections
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collections

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