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Title: Phenolic profile, antioxidant and cholinesterase inhibitory activities of four Trametes species: T. bicolor, T. pubescens, T. suaveolens, and T. versicolor
Authors: Çayan, Gülsen Tel
Çayan, Fatih
Deveci, Ebru
Duru, Mehmet Emin
Keywords: Trametes Species
Anticholinesterase Activity
Phenolic Compounds
Antioxidant Activity
Mild Cognitive Impairment
Oxidative Stress
Medicinal Mushrooms
Issue Date: 2021
Publisher: SPRINGER
Abstract: Trametes genus is one of the most important medicinal mushroom species in the world. The present study focused on phenolic profile, cholinesterase inhibitory and antioxidant activities of four Trametes species (T. bicolor, T. pubescens, T. suaveolens and T. versicolor). Phenolic profiles of the mushrooms were characterized by HPLC-DAD. ABTS(center dot+) scavenging, beta-carotene-linoleic acid, Cupric-reducing antioxidant capacity (CUPRAC), DPPH center dot scavenging, and metal chelating assays were performed to evaluate antioxidant activities of the extracts. Ellman method was used to test butyrylcholinesterase (BChE) and acetylcholinesterase (AChE) inhibitory activities of the extracts. The most abundant compound was fumaric acid (4.51 +/- 0.10 mu g/g) in T. bicolor, trans-cinnamic acid (0.49 +/- 0.05 mu g/g) in T. pubescens, catechin hydrate in T. suaveolens (0.92 +/- 0.16 mu g/g) and T. versicolor (0.96 +/- 0.19 mu g/g). T. pubescens acetone extract showed the highest antioxidant activity in CUPRAC (A(0.50): 19.26 +/- 0.21 mu g/mL), ABTS(center dot+) (IC50: 3.55 +/- 0.16 mu g/mL), DPPH center dot (85.12 +/- 0.44%)(,) beta-carotene-linoleic acid (IC50: 1.12 +/- 0.41 mu g/mL) assays. The best metal chelating activity was found in T. versicolor hexane extract (56.78 +/- 0.63%). It was determined that T. pubescens hexane extract (IC50: 7.37 +/- 0.55, 15.24 +/- 0.98 mu g/mL, respectively) showed higher AChE and BChE inhibitory activities. The results of this study support the potential use of Trametes species to design new functional drug formulations.
ISSN: 2193-4126
Appears in Collections:Mühendislik ve Doğa Bilimleri Fakültesi Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collections
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collections

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