Please use this identifier to cite or link to this item:
https://hdl.handle.net/20.500.13091/1004
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Molo, Zeynep | - |
dc.contributor.author | Çayan, Gülsen Tel | - |
dc.contributor.author | Deveci, Ebru | - |
dc.contributor.author | Öztürk, Mehmet | - |
dc.contributor.author | Duru, Mehmet Emin | - |
dc.date.accessioned | 2021-12-13T10:32:19Z | - |
dc.date.available | 2021-12-13T10:32:19Z | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 2212-4292 | - |
dc.identifier.issn | 2212-4306 | - |
dc.identifier.uri | https://doi.org/10.1016/j.fbio.2021.101201 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.13091/1004 | - |
dc.description.abstract | Chaerophyllum species are used as a food additive with their unique aroma and in traditional treatment with beneficial health effects. In this study, various extracts of Chaerophyllum bulbosum L. aerial parts were investigated in terms of the isolation of compounds and ability to inhibit enzyme (AChE, BChE urease, tyrosinase, alpha-amylase, and alpha-glucosidase) activities. The hexane extract showed higher inhibitory activity against all enzymes except urease. Nine compounds, n-octacosane (1), n-heptadecanyl eicosanoate (2), stigmasterol (3), beta-sitosterol-3-O-beta-D-glucopyranoside (4), quercetin-3-O-beta-D-glucopyranoside (5), apigenin-7-O-beta-D-glucopyr-anoside (6), luteolin-7-O-beta-D-glucopyranoside (7), sucrose (8), and luteolin-7-O-alpha-D-glucopyranoside-4 ''-O-beta-D-glucopyranoside (9) were purified from C. bulbosum and their chemical structures were defined by confirming their IR, NMR, and MS data with the literature. Antioxidant and enzyme inhibitory activities of all purified compounds were searched. Compounds 5 and 7 were found to have higher DPPH. and ABTS.+ scavenging activities than standards BHA and alpha-tocopherol. 1 (IC50: 1.63 +/- 0.05 mu g/mL), 2 (IC50: 2.02 +/- 0.13 mu g/mL) and 3 (IC50: 5.36 +/- 0.22 mu g/mL) had higher urease inhibition activity than thiourea (IC50: 7.87 +/- 0.18 mu g/mL) used as a standard. In addition, it was determined that compound 7 (IC50: 352.63 +/- 0.23 mu g/mL) exhibited higher alpha-glucosidase enzyme inhibitory activity as compared to acarbose (IC50: 378.66 +/- 0.14 mu g/mL) while it showed a competitive activity against alpha-amylase. The results reveal that C. bulbosum can be used as a natural source for developing plant-based formulations in fields such as food, pharmaceutical, and cosmetics. | en_US |
dc.description.sponsorship | Scientific and Technological Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [TUBITAK-118Z610] | en_US |
dc.description.sponsorship | The authors would like to thank Dr. Yeter Yesil for the identification of the plant sample. This study was supported by grants from The Scientific and Technological Research Council of Turkey (TUBITAK-118Z610) . | en_US |
dc.language.iso | en | en_US |
dc.publisher | ELSEVIER | en_US |
dc.relation.ispartof | FOOD BIOSCIENCE | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | C. Bulbosum | en_US |
dc.subject | Aerial Part | en_US |
dc.subject | Isolation | en_US |
dc.subject | Characterization | en_US |
dc.subject | Enzyme Inhibitory Activity | en_US |
dc.subject | Antioxidant Activity | en_US |
dc.subject | Bioactive Secondary Metabolites | en_US |
dc.subject | Inhibitory-Activity | en_US |
dc.subject | Alpha-Glucosidase | en_US |
dc.subject | Chemical-Constituents | en_US |
dc.subject | Flavonoids | en_US |
dc.subject | Glycosides | en_US |
dc.subject | Plants | en_US |
dc.subject | Cytotoxicity | en_US |
dc.subject | Kinetics | en_US |
dc.subject | Luteolin | en_US |
dc.title | Insight into isolation and characterization of compounds of Chaerophyllum bulbosum aerial part with antioxidant, anticholinesterase, anti-urease, anti-tyrosinase, and anti-diabetic activities | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1016/j.fbio.2021.101201 | - |
dc.identifier.scopus | 2-s2.0-85109094362 | en_US |
dc.department | Fakülteler, Mühendislik ve Doğa Bilimleri Fakültesi, Kimya Mühendisliği Bölümü | en_US |
dc.authorid | Tel-Cayan, Gulsen/0000-0002-1916-7391 | - |
dc.authorwosid | DURU, Mehmet Emin/ABA-2426-2021 | - |
dc.identifier.volume | 42 | en_US |
dc.identifier.wos | WOS:000687654900004 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 57224941069 | - |
dc.authorscopusid | 57194732739 | - |
dc.authorscopusid | 56089358000 | - |
dc.authorscopusid | 7102665882 | - |
dc.authorscopusid | 12789661400 | - |
dc.identifier.scopusquality | Q1 | - |
item.grantfulltext | embargo_20300101 | - |
item.cerifentitytype | Publications | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.languageiso639-1 | en | - |
item.openairetype | Article | - |
crisitem.author.dept | 07. 04. Department of Chemistry and Chemical Processing Technologies | - |
Appears in Collections: | Mühendislik ve Doğa Bilimleri Fakültesi Koleksiyonu Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collections WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collections |
Files in This Item:
File | Size | Format | |
---|---|---|---|
1-s2.0-S2212429221003266-main.pdf Until 2030-01-01 | 1.59 MB | Adobe PDF | View/Open Request a copy |
CORE Recommender
WEB OF SCIENCETM
Citations
6
checked on Jul 20, 2024
Page view(s)
170
checked on Jul 22, 2024
Download(s)
8
checked on Jul 22, 2024
Google ScholarTM
Check
Altmetric
Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.