Teknik Bilimler Meslek Yüksekokulu Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.13091/1629

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Browsing Teknik Bilimler Meslek Yüksekokulu Koleksiyonu by Subject "Alpha-Glucosidase"

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    Article
    Citation - WoS: 21
    Citation - Scopus: 22
    Hplc-Dad Characterization of Phenolic Profile and in Vitro Antioxidant, Anticholinesterase, and Antidiabetic Activities of Five Mushroom Species From Turkey
    (Springer Heidelberg, 2021) Çayan, Fatih; Tel-Çayan, Gülşen; Deveci, Ebru; Duru, Mehmet Emin
    In this study, Daedalea quercina (L.) Pers., Hydnum repandum L., Inonotus radiatus (Sowerby) P. Karst., Omphalotus olearius (DC.) Singer, and Schizophyllum commune Fr. hexane and methanol extracts were subjected to the spectrophotometric assays for antioxidant and enzyme inhibitory activities, which are linked with human diseases that are very prevalent in recent years. Additionally, phenolic compounds of the mushrooms were quantified by HPLC-DAD. The best antioxidant activity was found in H. repandum methanol extract (IC50: 12.04 +/- 0.24 mu g/mL) in the beta -carotene-linoleic assay; I. radiatus methanol extract in DPPH center dot (81.22 +/- 0.50%), ABTS(center dot+) (IC50: 73.47 +/- 0.18 mu g/mL), and CUPRAC (A(0.50): 88.21 +/- 0.02 mu g/mL) assays; S. commune hexane extract (53.36 +/- 0.89%) in the metal chelating assay. O. olearius hexane extract was found as the best inhibitor against AChE (71.58 +/- 0.28%) and BChE (67.30 +/- 0.15%). When I. radiatus methanol (95.88 +/- 0.74%) and H. repandum hexane (95.75 +/- 0.16%) extracts showed close alpha -amylase inhibitory activity to acarbose (96.68 +/- 0.08%), D. quercina methanol extract (70.79 +/- 0.34%) had higher alpha -glucosidase inhibitory activity than acarbose (67.01 +/- 2.28%). Among 16 phenolic compounds analyzed, gallic acid (0.02 +/- 0.01-0.23 +/- 0.01 mu g/g) was detected in all studied mushrooms. This study provides that investigated mushrooms can be used for further research, which can lead to the development of new natural remedies to alleviate complications related to oxidative stress, diabetes, and neurological diseases.