Browsing by Author "Tel-Çayan, Gülşen"

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    Citation - WoS: 21
    Citation - Scopus: 22
    Hplc-Dad Characterization of Phenolic Profile and in Vitro Antioxidant, Anticholinesterase, and Antidiabetic Activities of Five Mushroom Species From Turkey
    (Springer Heidelberg, 2021) Çayan, Fatih; Tel-Çayan, Gülşen; Deveci, Ebru; Duru, Mehmet Emin
    In this study, Daedalea quercina (L.) Pers., Hydnum repandum L., Inonotus radiatus (Sowerby) P. Karst., Omphalotus olearius (DC.) Singer, and Schizophyllum commune Fr. hexane and methanol extracts were subjected to the spectrophotometric assays for antioxidant and enzyme inhibitory activities, which are linked with human diseases that are very prevalent in recent years. Additionally, phenolic compounds of the mushrooms were quantified by HPLC-DAD. The best antioxidant activity was found in H. repandum methanol extract (IC50: 12.04 +/- 0.24 mu g/mL) in the beta -carotene-linoleic assay; I. radiatus methanol extract in DPPH center dot (81.22 +/- 0.50%), ABTS(center dot+) (IC50: 73.47 +/- 0.18 mu g/mL), and CUPRAC (A(0.50): 88.21 +/- 0.02 mu g/mL) assays; S. commune hexane extract (53.36 +/- 0.89%) in the metal chelating assay. O. olearius hexane extract was found as the best inhibitor against AChE (71.58 +/- 0.28%) and BChE (67.30 +/- 0.15%). When I. radiatus methanol (95.88 +/- 0.74%) and H. repandum hexane (95.75 +/- 0.16%) extracts showed close alpha -amylase inhibitory activity to acarbose (96.68 +/- 0.08%), D. quercina methanol extract (70.79 +/- 0.34%) had higher alpha -glucosidase inhibitory activity than acarbose (67.01 +/- 2.28%). Among 16 phenolic compounds analyzed, gallic acid (0.02 +/- 0.01-0.23 +/- 0.01 mu g/g) was detected in all studied mushrooms. This study provides that investigated mushrooms can be used for further research, which can lead to the development of new natural remedies to alleviate complications related to oxidative stress, diabetes, and neurological diseases.
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    Isolation and Characterization of Chemical Constituents From Chaerophyllum Bulbosum Roots and Their Enzyme Inhibitory and Antioxidant Effects
    (Walter De Gruyter Gmbh, 2022) Tel-Çayan, Gülşen; Deveci, Ebru; Molo, Zeynep; Duru, Mehmet Emin; Öztürk, Mehmet
    Isolation and bioactive effects of the roots of Chaerophyllum bulbosum L. were firstly investigated herein. Enzyme (acetylcholinesterase, butyrylcholinesterase, urease, alpha-amylase, alpha-glucosidase, and tyrosinase) inhibitory effects of C. bulbosum root extracts were tested. Three known compounds, n-heptadecanyl eicosanoate (1), stigmasterol (2), and beta-sitosterol-3-O-beta-d-glucopyranoside (3) were isolated from C. bulbosum. Antioxidant and enzyme inhibitory effects of isolated compounds were investigated. The hexane extract (IC50: 349.58 +/- 0.06 mu g/mL) displayed a higher alpha-glucosidase inhibitory effect than the standard (IC50: 378.66 +/- 0.14 mu g/mL). The best inhibitory effect was found in compound 2 on AChE (46.40 +/- 0.31%), BChE (56.41 +/- 0.54%), and urease (92.47 +/- 0.11%); compound 1 on alpha-amylase (22.27 +/- 0.61%); and compound 3 on alpha-glucosidase (12.43 +/- 0.25%) and tyrosinase (19.00 +/- 0.16%). All isolated compounds showed moderate antioxidant effects in all assays. This study contributes to the therapeutic uses of Chaerophyllum roots and emphasizes the value of C. bulbosum species for the development of novel therapeutic agents.