Browsing by Author "Martinez-Manez, Ramon"

Now showing 1 - 3 of 3

Citation - WoS: 25
Citation - Scopus: 29
Aerogels as Promising Materials for Antibacterial Applications: a Mini-Review
(ROYAL SOC CHEMISTRY, 2021) Kaya Güzel, Gülcihan; Aznar, Elena; Deveci, Hüseyin; Martinez-Manez, Ramon
The increasing cases of bacterial infections originating from resistant bacteria are a serious problem globally and many approaches have been developed for different purposes to treat bacterial infections. Aerogels are a novel class of smart porous materials composed of three-dimensional networks. Recently, aerogels with the advantages of ultra-low density, high porosity, tunable particle and pore sizes, and biocompatibility have been regarded as promising carriers for the design of delivery systems. Recently, aerogels have also been provided with antibacterial activity through loading of antibacterial agents, incorporation of metal/metal oxides and via surface functionalization and coating with various functional groups. In this mini-review, the synthesis of aerogels from both conventional and low-cost precursors is reported and examples of aerogels displaying antibacterial properties are summarized. As a result, it is clear that the encouraging antibacterial performance of aerogels promotes their use in many antibacterial applications, especially in the food industry, pharmaceutics and medicine.
Citation - WoS: 18
Citation - Scopus: 19
Antibacterial Activity of Linezolid Against Gram-Negative Bacteria: Utilization of Epsilon-Poly Capped Silica Xerogel as an Activating Carrier
(MDPI, 2020) Kaya Güzel, Gülcihan; Medaglia, Serena; Candela-Noguera, Vicente; Tormo-Mas, Maria Angeles; Marcos, Maria Dolores; Aznar, Elena; Martinez-Manez, Ramon
In recent times, many approaches have been developed against drug resistant Gram-negative bacteria. However, low-cost high effective materials which could broaden the spectrum of antibiotics are still needed. In this study, enhancement of linezolid spectrum, normally active against Gram-positive bacteria, was aimed for Gram-negative bacteria growth inhibition. For this purpose, a silica xerogel prepared from a low-cost precursor is used as a drug carrier owing to the advantages of its mesoporous structure, suitable pore and particle size and ultralow density. The silica xerogel is loaded with linezolid and capped with epsilon-poly-l-lysine. The developed nano-formulation shows a marked antibacterial activity against to Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. In comparison to free linezolid and epsilon-poly-l-lysine, the material demonstrates a synergistic effect on killing for the three tested bacteria. The results show that silica xerogels can be used as a potential drug carrier and activity enhancer. This strategy could provide the improvement of antibacterial activity spectrum of antibacterial agents like linezolid and could represent a powerful alternative to overcome antibiotic resistance in a near future.
Citation - WoS: 53
Citation - Scopus: 55
Low-Cost Silica Xerogels as Potential Adsorbents for Ciprofloxacin Removal
(ELSEVIER, 2021) Kaya Güzel, Gülcihan; Aznar, Elena; Deveci, Hüseyin; Martinez-Manez, Ramon
Ciprofloxacin, a second generation fluoroquinolone antibiotic, is one of the top pharmaceutical contaminants in water and many approaches have been developed for the removal of ciprofloxacin in wastewater. In this study, ciprofloxacin adsorption is carried out using a low-cost silica xerogel synthesized by a simple sol-gel method. The effect of pH, contact time, initial concentration of ciprofloxacin and temperature on the adsorption of ciprofloxacin by the silica xerogel is investigated. At optimum adsorption conditions, the experimental data fits well to a Langmuir isotherm and a pseudo-second-order kinetic model. The maximum ciprofloxacin adsorption capacity is determined as 24.45 mg g(-1). Thermodynamic parameters show that ciprofloxacin adsorption by the silica xerogel is a spontaneous endothermic process. Moreover, reusability experiments reveal that the silica xerogel can be effectively used several times for ciprofloxacin adsorption. The promising results indicate that the silica xerogel can be regarded as potential adsorbent for ciprofloxacin removal.