06. Meslek Yüksekokulları

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Browsing 06. Meslek Yüksekokulları by Author "Çayan, Gülsen Tel"

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    Citation - Scopus: 3
    Anti-Colorectal Cancer Effects of Medicinal Plants: Euphorbia Helioscopia, Ferula Elaeochytris, and Sideritis Albiflora
    (2021) Deveci, Ebru; Çayan, Gülsen Tel; Karakurt, Serdar; Duru, Mehmet Emin
    Phytochemicals, extracts, and mixtures obtained from plants have been offered as an option for cancer treatment and prevention for modern drug discovery in recent years. For this purpose, in this study, anti-colorectal cancer effects of the hexane, acetone, methanol, and water extracts obtained by sequential extraction from Euphorbia helioscopia L., Ferula elaeochytris Korovin, and Sideritis albiflora Hub.-Mor. on DLD-1 cell line were investigated in vitro by using Alamar blue assay. Dosedependent inhibition was detected in the viability of DLD-1 cell line. In all three plants species, E. helioscopia (IC50: 140.83±0.31 µg/mL), F. elaeochytris (IC50: 67.93±0.12 µg/mL), and S. albiflora (IC50: 85.12±0.10 µg/mL) methanol extracts showed higher anti-colorectal effects on DLD-1 cell line compared to other extracts tested for the same species. In addition, the IC50 value of doxorubicin used as a standard was found as 6.10±0.55 µg/mL. With the results obtained, as the first report highlighting in vitro anti-colorectal cancer effects of the studied plant species on DLD-1 cell line, promising marks were obtained from the analysis of the extracts as anti-cancer sources for plant-derived drug applications.
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    Citation - Scopus: 6
    Cytotoxic Activities of Methanol Extract and Compounds of Porodaedalea Pini Against Colorectal Cancer
    (2021) Deveci, Ebru; Çayan, Gülsen Tel; Karakurt, Serdar; Duru, Mehmet Emin
    Porodaedalea pini is a medicinally important mushroom with antioxidant, cytotoxic, immunostimulating, antitumor, antiviral and immunomodulating activities. Therefore, in this study, P. pini methanol extract and isolated compounds from the methanol extract were tested for cytotoxic activities against DLD-1 (colorectal cancer) and CCD-18Co (human colon fibroblast cell line) by using Alamar Blue assay. Cytotoxic activity on DLD-1 was decreased in the order of P. pini methanol extract> 4-(3,4- dihydroxyphenyl)but-3-en-2-one (3)> pinoresinol (2)> ergosta-7,24(28)-dien3?-ol (1). P. pini methanol extract was determined to have the best cytotoxic activity with the lowest IC50 value on DLD-1 (IC50: 25.33±0.29 µg/mL) and the highest IC50 value on CCD-18Co (434.30±1.45 µg/mL). Within the scope of the findings, it is thought that P. pini mushroom can be used as a new and natural agent in the treatment of colorectal cancer.
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    Citation - Scopus: 9
    In Vitro Antidiabetic Activity of Seven Medicinal Plants Naturally Growing in Turkey
    (2020) Deveci, Ebru; Çayan, Gülsen Tel; Duru, Mehmet Emin
    Objective: Diabetes mellitus is a worldwide metabolic/endocrine disease that causes major medical problems. One of the most important strategies used in the therapy of the diabetes mellitus is the use of inhibition of ?-glucosidase and ?-amylase enzymes. Therefore, this study aimed to investigate antidiabetic activities of the hexane and methanol extracts of the medicinal plants from Turkey. Materials and Methods: The hexane and methanol extracts of Euphorbia helioscopia, Ferula elaeochytris, Sideritis albiflora, Sideritis stricta, Sideritis pisidica, Sideritis leptoclada, Salvia chionantha plants were prepared at room temperature. Antidiabetic activities of the extracts on ?-glucosidase and ?-amylase enzymes were determined. Results: S. pisidica hexane extract exhibited higher ?-amylase inhibitory activity than acarbose (96.60±0.08 %) used as a standard with an inhibition value of 97.99±0.79 % at 1000 µg/mL concentration. In terms of ?-glucosidase inhibitory activities, the extracts were ranked in the following order: F. elaeochytris hexane extract > S. leptoclada hexane extract > S. stricta hexane extract > E. helioscopia hexane extract. Conclusion: In this study, antidiabetic activities of the extracts on ?-glucosidase and ?-amylase enzymes of the studied medicinal plants were screened for the first time. It has been suggested that S. pisidica hexane extract can be used as antidiabetic agent.