PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collections
Permanent URI for this collectionhttps://hdl.handle.net/20.500.13091/5
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Browsing PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collections by Author "Akpınar, Merve"
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Article Citation - WoS: 25Citation - Scopus: 22A Phenyl Glycinol Appended Calix[4]arene Film for Chiral Detection of Ascorbic Acid on Gold Surface(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2019) Akpınar, Merve; Temel, Farabi; Tabakcı, Begüm; Özçelik, Egemen; Tabakcı, MustafaThis paper describes the synthesis of new chiral calix [4]arene derivative having (R)-2-phenylglycinol moiety (compound 6), and its chiral recognition studies for ascorbic acid (AA) enantiomers by using Quartz Crystal Microbalance (QCM). Initial experiments indicated that the outstanding selective chiral recognition (alpha) was observed as 2.61 for L-enantiomer of AA. The sensitivity (S) and the limit of detection (LOD) values for L-AA were calculated as 0.0226 Hz/mu M and 0.63 mu M, respectively. Furthermore, the sorption behavior and mechanism of AA onto compound 6 film were evaluated and the sorption data exhibited a good correlation with the Freundlich isotherm models. The maximum uptake of L-AA by the sensor was found as 5895.76 mg/g. In conclusion, chiral recognition of AA enantiomers as real-time, sensitive, selective and effective was performed by a calixarene derivative coated QCM sensor.Article Citation - WoS: 29Citation - Scopus: 28Selective Chiral Recognition of Alanine Enantiomers by Chiral Calix[4]arene Coated Quartz Crystal Microbalance Sensors(SPRINGER HEIDELBERG, 2019) Temel, Farabi; Erdemir, Serkan; Tabakcı, Begüm; Akpınar, Merve; Tabakcı, MustafaWe describe the synthesis of new chiral calix[4]arene derivatives having (R)-1-phenylethylamine, (S)-1-phenylethylamine, (R)-2-phenylglycinol, and (S)-2-phenylglycinol moieties, and chiral recognition studies for enantiomers of some selected -amino acid derivatives such as alanine, phenylalanine, serine, and tryptophan using a quartz crystal microbalance (QCM). Initial experiments indicated that the highest selective chiral recognition factor was 1.42 for alanine enantiomers. The sensitivity, limit of detection, and time constant for l-alanine were calculated as 0.028 Hz/M, 60.9 M, and 36.2 s, respectively. The results indicated that real-time, sensitive, selective, and effective chiral recognition of alanine enantiomers was achieved with a QCM sensor coated with a chiral calix[4]arene derivative having (R)-2-phenylglycinol moieties.
