Doğan, NurettinYapar, Kürşad Buğrahan2026-03-102026-03-1020252618-575Xhttps://doi.org/10.35860/iarej.1681592https://search.trdizin.gov.tr/en/yayin/detay/1378893/comparative-study-on-most-used-modern-symmetric-encryption-algorithms-for-breast-cancer-ultrasound-imageshttps://hdl.handle.net/20.500.13091/13094In this study, several prominent symmetric encryption algorithms, including AES, Blowfish, DES, 3DES, and RC4, were applied to encrypt breast ultrasound images. These algorithms were further compared with RSA, a representative asymmetric encryption method. Three different breast ultrasound images, categorized as benign tumor, malignant tumor, and normal tissue, were used in the encryption process. Each image was provided in two file formats (PNG and BMP) and at two resolutions (256 × 256 and 512 × 512 pixels). The performance of the algorithms was evaluated using metrics such as the Number of Pixel Change Rate (NPCR), Unified Average Changing Intensity (UACI), histogram analysis, and encryption and decryption times. The experimental results demonstrated that symmetric encryption algorithms were more efficient than their asymmetric counterpart. Additionally, a comparative analysis of the symmetric algorithms was conducted, along with a discussion of their relative performance.eninfo:eu-repo/semantics/openAccessBilgisayar BilimleriTeori ve MetotlarArticle10.35860/iarej.1681592