Temel, FarabiErdemir, SerkanTabakcı, BegümAkpınar, MerveTabakcı, Mustafa2021-12-132021-12-1320191618-26421618-2650https://doi.org/10.1007/s00216-019-01705-5https://hdl.handle.net/20.500.13091/1376We describe the synthesis of new chiral calix[4]arene derivatives having (R)-1-phenylethylamine, (S)-1-phenylethylamine, (R)-2-phenylglycinol, and (S)-2-phenylglycinol moieties, and chiral recognition studies for enantiomers of some selected -amino acid derivatives such as alanine, phenylalanine, serine, and tryptophan using a quartz crystal microbalance (QCM). Initial experiments indicated that the highest selective chiral recognition factor was 1.42 for alanine enantiomers. The sensitivity, limit of detection, and time constant for l-alanine were calculated as 0.028 Hz/M, 60.9 M, and 36.2 s, respectively. The results indicated that real-time, sensitive, selective, and effective chiral recognition of alanine enantiomers was achieved with a QCM sensor coated with a chiral calix[4]arene derivative having (R)-2-phenylglycinol moieties.eninfo:eu-repo/semantics/closedAccessAmino AcidCalixareneAlanineChiral RecognitionQuartz Crystal Microbalance SensorQcm SensorsResonant-FrequencyDiscriminationImmunosensorOptimizationInterfaceArrayArticle10.1007/s00216-019-01705-52-s2.0-85064271610