Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.13091/3201
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dc.contributor.authorFilik, Hayati-
dc.contributor.authorAvan, Asiye Aslihan-
dc.contributor.authorPuntar, Nilay Altas-
dc.contributor.authorÖzyürek, Mustafa-
dc.contributor.authorÇakıcı, Maside-
dc.contributor.authorGuengor, Zeynep Banu-
dc.contributor.authorKamış, Handan-
dc.date.accessioned2022-11-28T16:57:06Z-
dc.date.available2022-11-28T16:57:06Z-
dc.date.issued2022-
dc.identifier.issn0026-265X-
dc.identifier.issn1095-9149-
dc.identifier.urihttps://doi.org/10.1016/j.microc.2022.107990-
dc.identifier.urihttps://doi.org/10.1016/j.microc.2022.107990-
dc.identifier.urihttps://hdl.handle.net/20.500.13091/3201-
dc.description.abstractIn this approach, we fabricated a sandwich-type electrochemical immunosensor for individual and simultaneous sensing of cytokeratin fragment antigen 21-1 (CYFRA 21-1) and neuron-specific enolase (NSE) using the multiple-label concept. In this report, carbon dots (CDs) were prepared from citric acid and ethylenediamine (EDA). A hybrid EDA-CDs-MWCNTs composites were prepared and then decorated with gold nanoparticles (AuNPs). The obtained hybrid composites were used as an immunosensing platform. Furthermore, AuNPs decorated EDA-CDs-MWCNTs was carefully loaded with reactive dye (orange G and carminic acid) and utilized as signal labels. The surface morphology and the electrochemical properties of the modified SPCE were studied carefully. The linear range for the individual and simultaneous detection was 0.002-10 ng mL-1 for the CYFRA 21-1 and NSE and the detection limits (LODs) were 0.22 pg mL-1 and 0.15 pg mL-1 for the individual detection while 0.25 pg mL-1 and 0.20 pg mL-1 for simultaneous detection, respectively. This developed immunoassay was utilized for the assessment of two markers in the serum sample with reasonable consequences.en_US
dc.description.sponsorship[33470]en_US
dc.description.sponsorshipAcknowledgements This current study was supported by the Research Fund of the Istanbul University-Cerrahpas ? a (Project No. 33470) . The authors gratefully acknowledge the Istanbul University-Cerrahpas ? a.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofMicrochemical Journalen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCytokeratin fragment antigen 21-1en_US
dc.subjectNeuron-specific enolaseen_US
dc.subjectImmunosensoren_US
dc.subjectVoltammetryen_US
dc.subjectSerum analysisen_US
dc.subjectMultiple Tumor-Markersen_US
dc.subjectCell Lung-Canceren_US
dc.subject4 Biomarkersen_US
dc.subject3d Grapheneen_US
dc.subjectImmunoassayen_US
dc.subjectBiosensorsen_US
dc.subjectNanocompositesen_US
dc.subjectNanoparticlesen_US
dc.subjectOxidationen_US
dc.subjectPlatformen_US
dc.titleElectrochemical immunosensor for individual and simultaneous determination of Cytokeratin fragment antigen 21-1 and Neuron-specific enolase using carbon dots-decorated multiwalled carbon nanotube electrodeen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.microc.2022.107990-
dc.identifier.scopus2-s2.0-85138568884en_US
dc.departmentFakülteler, Mühendislik ve Doğa Bilimleri Fakültesi, Kimya Mühendisliği Bölümüen_US
dc.identifier.volume183en_US
dc.identifier.wosWOS:000863129200007en_US
dc.institutionauthorKamış, Handan-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.authorscopusid6602141017-
dc.authorscopusid55761557800-
dc.authorscopusid57900540200-
dc.authorscopusid7801551787-
dc.authorscopusid57701397400-
dc.authorscopusid6602676539-
dc.authorscopusid18042113100-
dc.identifier.scopusqualityQ1-
item.openairetypeArticle-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextembargo_20300101-
item.fulltextWith Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.dept02.01. Department of Chemical Engineering-
Appears in Collections:Mühendislik ve Doğa Bilimleri Fakültesi Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collections
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collections
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